| Title | A Highly Selective Fluorescent Probe for Thiol Bioimaging. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Bouffard, J, Kim, Y, Swager, TM, Weissleder, R, Hilderbrand, SA |
| Journal | Organic Letters |
| Volume | 10 |
| Pagination | 37–40 |
| ISSN | 1523-7060 |
| Keywords | selective fluorescent probe thiol bioimaging |
| Abstract | A new fluorescent turn-on probe (I) for the selective sensing and bioimaging of thiols is reported. In aq. buffer solns. at physiol. pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore. The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated. [on SciFinder(R)] |
| DOI | 10.1021/ol702539v |