Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology.

TitleSmart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology.
Publication TypeJournal Article
Year of Publication2008
AuthorsRaymond, SB, Skoch, J, Hills, ID, Nesterov, EE, Swager, TM, Bacskai, BJ
JournalEuropean journal of nuclear medicine and molecular imaging
Volume35 Suppl 1
PaginationS93–8
Date Publishedmar
ISSN1619-7070
KeywordsAlzheimer Disease, Alzheimer Disease: pathology, Animals, Brain, Brain: pathology, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: diagnostic use, Humans, Microscopy, Molecular Probe Techniques, Near-Infrared, Near-Infrared: methods, Spectroscopy
Abstract

Near-infrared fluorescent probes for amyloid-beta (Abeta) are an exciting option for molecular imaging in Alzheimer's disease research and may translate to clinical diagnostics. However, Abeta-targeted optical probes often suffer from poor specificity and slow clearance from the brain. We are designing smart optical probes that emit characteristic fluorescence signal only when bound to Abeta.
URLhttp://www.ncbi.nlm.nih.gov/pubmed/18236039
DOI10.1007/s00259-007-0708-7